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Theoretically, the current regimens pursuing clinical cure are mainly based on IFN

While both gene and cell therapies are promising, and offer the potential of curative therapies, there are currently many barriers to their widespread adoption, including the costs of greater than $1.0 MM US for these treatments

In addition, reduced DA production and elevated inflammatory markers in the substantia nigra compacta and impaired DA metabolism in the striatum were also observed (Supplemental Figure 1, MQ)

Decursin and decurinol angelate were tested in vitro and demonstrated improved wound healing through upregulated transcription of genes encoding extracellular matrix remodeling proteins, inflammatory cytokines, and growth factors in HaCaT human keratinocytes (Han et al., 2018)

Our data further indicate that Mg-L-theanine compounds with different Mg 2+ ratios, novel L-theanine agents, show even better improvement on sleep disturbance and sleep disturbance-related neurochemical changes