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Similarly, authors [3] of the first double-blind, randomized, placebo-controlled clinical trial of oral glutathione supplementation performed in healthy adult humans concluded that despite the biochemical plausibility, optimal dose, recommended timing of administration and appropriate choice of outcome measures, no significant changes were observed in oxidative stress biomarkers or erythrocyte glutathione concentrations following 4 weeks of oral (2 x 500mg daily) glutathione supplementation

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Phase 4: the 1.7mg acceleration dose (34 units) The jump from 1.0mg to 1.7mg is the largest single escalation in the standard protocol, a 0.7mg increase compared to the 0.25mg and 0.5mg jumps earlier