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Under normal conditions, robust antioxidant defense systems - including glutathione peroxidase (GPx), thioredoxin reductase, and superoxide dismutase - neutralize this HO before it can damage thyroid cells

[6] [9] Converted to mass, that is roughly 1,485 mcg (about 1.5 mg) for a 70 kg adult roughly fifteen times the ~100 mcg figure most commonly encountered in vendor and forum material, itself an unsourced convention with no published basis we could identify

doi:10.1038/emboj.2011.105 Kumar, C., Sharma, R., & Bachhawat, A

A medical perspective on the normal process and what to look out for

In elephant seals, repetitive spontaneous sleep apneas result in blood oxygen depletion, reduced muscle blood flow, decreased tissue P O2 , and increased 4-HNE, nuclear Nrf2 levels, and antioxidant enzyme expression in skeletal muscle (Ponganis et al., 2002, 2006, 2008