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R 4-OH catechol estrogens that are not methylated by COMT can be oxidized to quinones that generate reactive oxygen species and form DNA adducts, a mechanism implicated in estrogen-dependent cancers

Collagen and Elastin Synthesis: GHK-Cu and BPC-157 both upregulate collagen and elastin production, improving tissue elasticity, structural strength, and aesthetic recovery following injury or stress 1,3

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The use of such an ROS-responsive nanoplatform for drug formulation modification may provide a new strategy for not only the delivery of deucravacitinib but also other small-molecule drugs in the JAK family, which can offer a promising clinical translation strategy