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After 12 h, the samples were centrifuged and measured by fluorescence spectra

Consequently, our study highlights that meldonium increases the overall ATP produced in the cerebral cortex and hippocampus of MCAO rats and inhibits excessive mPTP opening, indicating that meldonium may protect neuronal survival by inhibiting mitochondria-dependent apoptosis and maintaining basic mitochondrial function

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321 TakaiS.YasumatsuK.InoueM.IwataS.YoshidaR.ShigemuraN.et al (2015)

Cerebral ischemia/reperfusion injury and pharmacologic preconditioning as a strategy to minimise stroke-induced inflammation and damage