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Importantly, with time the majority of relapse-onset patients will transition to a clinically progressive course [known as secondary progressive MS (SPMS)] characterized by cytodegeneration, while the inflammatory component wanes with age (Compston and Coles, 2008)

D., Baban, B., Harding, H

In September 2015, researchers from Virginia Polytechnic Institute and State University released results from a study of 252 Flint homes showing that 40 percent had water with elevated levels of lead, including one with levels twice what the Environmental Protection Agency (EPA) considers to be hazardous waste

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Validating robust, non-invasive biomarkers (e.g., circulating lipid peroxide metabolites, urine exosomal ferroptosis regulators, or TME-derived immune cell ferroptosis signatures) is urgently needed to guide clinical trial design and patient stratification