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The species has a broad but disjunct distribution, with documented populations in the Pearl, Upper Tombigbee, Alabama, Cahaba, Etowah and Conasauga river systems

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Unlike nuclear DNA mutations, which are typically binary (heterozygous or homozygous), mtDNA heteroplasmy exists on a continuous spectrum from 0% to 100%, introducing a non-Mendelian source of phenotypic variability that can influence tumor evolution 11

The reduced novel GSH synthesis under acidosis may explain the increased demand for NADPH to recycle existing pools of GSH

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