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5 Exercise as a modulator of musclevasculature interactions 5.1 Exercise-induced signaling pathways improving endothelial and muscle function Exercise constitutes a robust, pleiotropic stimulus that orchestrates adaptive responses in both skeletal muscle and the vascular endothelium, thereby facilitating the restoration and preservation of the musclevasculature axis, which tends to deteriorate with advancing age

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Secondary aim: Assessment of the protective effect of L-carnitine on bowel function and habits in patients with DRE on KD by assessing frequency of defecation, stool form and response to laxatives