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10.1016/s0891-5849(01)00769-9 3 BegricheK.IgoudjilA.PessayreD.FromentyB

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Pharmacokinetic studies showed that the modified M-NPs had higher blood retention and lower liver uptake, resulting in enhanced effectiveness for suppressing inflammatory cytokines in models of lipopolysaccharide-induced lung injury and endotoxemia

Thus, evidences suggest that diamidines interfere in the kinetoplast function of trypanosomatids through a selective association to the unique AT-rich regions of kDNA minicircles, perhaps involving DNA-processing enzymes [146]