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For advanced solid tumors and melanoma, HCQ combined with 150 mg/m 2 of temozolomide showed 27% stable disease and 14% partial response in wildtype melanoma (Cheng et al., 2009

It has also been reported that glutathione plays a role in the redox pathway of mitochondrial dynamics regulation in axons (Mariet et al

[DOI] [PMC free article] [PubMed] [Google Scholar] 90.Kita S, Maeda N, Shimomura I

Phases I and II enzymes catalyze the conversion of a lipophilic, non-polar xenobiotic into a more water-soluble and therefore less toxic metabolite, which can then be more easily excreted from the body