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elegans neurons, promoter sequences of ser-1 (2103 bp), tbh-1 (4537 bp), or glr-3 (2838 bp) were inserted into the pSM::SL2::GFP::short unc-54 3 UTR vector along with a ser-1 cDNA

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Although the exact mechanism is not known, it has been proposed that the positively charged LNP component facilitates interaction with the negatively charged endosomal membrane leading to ATP-driven acidification

Unlike many peptides that degrade rapidly in the digestive system, BPC-157 demonstrates remarkable stability in gastric acid, which has contributed to interest in both injectable and oral administration routes