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Lipid hydroperoxides, generated primarily through the activity of lipoxygenases (LOXs), are key mediators of cellular dysfunction and death ( 2.1.3 Antioxidant system 2.1.3.1 System Xc-/GSH/GPX4 axis The cystine/glutamate antiporter (System Xc-), glutathione (GSH), and glutathione peroxidase 4 (GPX4) form a critical antioxidant axis that plays a central role in regulating ferroptosis

Several preclinical and clinical studies have demonstrated the therapeutic usefulness of RSV in several chronic illnesses such as arthritis, diabetes, neoplastic, and neurodegenerative diseases (Saiko et al., 2008)

Glutathione the body's master antioxidant works from the inside out to inhibit melanin production and reverse oxidative stress that causes skin darkening