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In the fish brain, glutathione also indirectly regulates neurotransmission by influencing the synthesis and metabolism of key neurotransmitters such as glutamate and gamma-aminobutyric acid (GABA), given that glutathione is synthesized from glutamate [77]

Furthermore, ROS interacts with cellular transduction pathways like protein kinase C/extracellular signal-regulated kinases (ERK)/mitogen-activated protein kinase (MAPK) pathway that can affect cell growth, cell proliferation, differentiation, apoptosis and gene expression [10, 11]

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7E, many neuronal cells were hyperstained with pyknosis, with an unclear boundary between the cytoplasm and nucleus and irregularly shaped cells in the brain tissues of PD mice