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As a water-soluble vitamin, excess B12 is excreted in urine, and no upper limit has been set in the UK due to its low toxicity

The ordering provider or institution assumes full responsibility for all regulatory compliance, clinical decision-making, and appropriate use within the scope of their professional license.

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Treatment may be needed for a minimum of three to six months.Prescription: In the United States, it is a prescription medicine and a controlled substance in many countries

Some people find that they prefer to have smaller quantities of B12 injected weekly or fortnightly, and others would rather take larger doses of B12 monthly