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The associated accession numbers, coordinates and structure factors of the crystallographic complexes reported in this paper are available from the Protein Data Bank (PDB) with accession codes PDB: 8FI9 and 8FHY

Dihexa half life (one to three hours) measures the time required for plasma concentrations to decline by 50%, while therapeutic window refers to the duration during which receptor activation drives neuroplasticity changes which extends for hours beyond plasma clearance

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