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p53 can downregulate the expression of the Xc system component SLC7A11, inhibiting cystine intake and inducing ferroptosis [61]

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While specific pro-oxidant initiators have not yet been identified, candidates with low oxidation potentials include metals, either derived from device coils or leftover from the manufacturing process, and Furaneol, 4-hydroxy-2,5-dimethyl-furan-3-on, known as strawberry or pineapple furanone, which has a low oxidation potential and has been implicated in the initiation of some cellular metal-dependent radical processes

Collectively, GGCT functions as a metabolic rheostat that orchestrates mitochondrial homeostasis through diverting Gln flux toward glutathione biosynthesis to fortify redox defense, while enhancing Glc-fueled TCA cycle anaplerosis to sustain cell proliferation

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