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Gastroenterology 158(7):18991912

The treatments were carried out once/daily, 5 days/week, at 1.09 ATA/4560 min of total treatment time for 20 treatments, 1-week break, repeat 20 treatments

found that the downregulation of the tankyrase PARP reduced cytoplasmic TDP-43 accumulation and potently attenuated neurodegeneration in a Drosophila model 132