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For example, the neurotoxin models of PD (using MPTP or 6-OHDA) recapitulate features of the diseaseelevated -synuclein, astrocyte activation, bloodbrain barrier disruption, inflammation, oxidative stress, and dopaminergic neuron lossand these models have demonstrated the neuroprotective potential of various dietary polyphenols (10)

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Simeone DM, Hecht J, Patel SP, Morelli MP, Kirtane K, Borad MJ, Maus MV, Sunwoo JB, Welling T, Lin Y, Garon EB, Kopetz S , Locke FL, Liechty KB, Lozac'hmeur A, Beutner K, Ng EW, Go WY, Maloney DG, Molina JR

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