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This mechanism maintains mitochondrial network integrity and prevents unwanted mitochondrial divisions [58, 88]

Ethics declarations Ethics approval and consent to participate The work was conducted in accordance with the ethical treatment criteria for laboratory animals, as specified in the Guide for the Care and Use of Laboratory Animals and the ARRIVE guidelines for reporting animal research

Mechanistically, the incubation of hemin with thiols (GSH, NAC, cysteine, mercaptoethanol, and thioglycolic acid) provokes major spectrophotometric changes in hemin despite the presence of low-affinity binders in serum [222]