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Supplements may be beneficial for women who: Eat a vegetarian or vegan diet Have confirmed vitamin B12 deficiency Are pregnant (as advised by a doctor) Have absorption disorders Have undergone bariatric surgery Take medications that reduce vitamin B12 absorption Supplements are available as: Tablets Capsules Sublingual tablets Oral sprays Injections (for severe deficiency) Always consult a healthcare professional before starting supplementation

10.1038/s41419-020-2334-2 114 YanH.HuangZ.BaiQ.ShengY.HaoZ.WangZ.et al (2018)

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Therefore, targeted small molecule inhibitors of the NNMT could be significantly beneficial as molecular probes for mechanistic investigations and for the development of therapeutics for the treatment of metabolic and chronic disease conditions that are characterized by abnormal NNMT activity

Penicillamine and its analogues dPenicillamine is a drug to chelate metals in tissue and promotes its excretion in the urine