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The therapeutic potential of targeting the SIRT1/Nrf2/HO-1/GPX4 pathway is further supported by research indicating that edaravone, a widely used anesthetic, mitigates depression and anxiety by inhibiting ferroptosis through this pathway (Shen et al., 1826)

Bristol Myers Squibbs Sotyktu (deucravacitinib), one of several treatments for psoriasis approved in 2022, is the first drug to include deuterium from its inception