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2.2 Intra-VLP nucleic acid encapsulation technologies While Section 2.1 Extra-VLP protein antigen display technologies detailed the spatial orchestration of surface antigens to dictate immune recognition, the interior lumen of the VLP offers a sequestered and shielded microenvironment for the encapsulation of functional nucleic acids, such as immunostimulatory CpG oligonucleotides or therapeutic mRNA