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Initial research focused on its role in wound healing and tissue remodeling, where it was found to modulate the expression of extracellular matrix (ECM) proteins such as collagen and elastin

Metformin reduces intestinal absorption of Vit B12 in up to 30% of patients, and dose-dependently lowers serum Vit B12 level in 5-10% of patients (Aroda et al, 2016