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However, skin toxicity affects around 90% of patients treated.1 Over 100 years ago it was observed that the growth of malignant tumors was associated with a proliferation of blood vessels.2 The hypothesis that tumor cells could produce proangiogenic substances was first proposed in 1968,3,4 and in 1971 Folkman5 published a hypothesis on the therapeutic potential of the inhibition of angiogenesis in cancer, marking the beginning of a new era in cancer research

Finally, the TAP2 protein is involved in antigen presentation 60

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Berthiaume JM, Oliveira PJ, Fariss MW, Wallace KB

( H ) Analysis was conducted using 2-way repeated-measures ANOVA to assess main effects