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However, the active was limited for use because of significant incidence of cardiovascular complications in patients on chronic ALV (0.5 mg/1 mg twice daily) for varying period of 6 to 12 weeks 48

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Deprived of this critical precursor, the cell loses its capacity to sustain de novo GSH synthesis

Similarly, fusion proteins like mitofusin 1 (Mfn1), mitofusin 2 (Mfn2), and optic atrophy 1 (OPA1) are downregulated, compromising the redistribution of metabolites and mtDNA and leading to mitochondrial fragmentation and dysfunction (Zheng et al., 2023)

The PNPLA3 variant associated with fatty liver disease (I148M) accumulates on lipid droplets by evading ubiquitylation