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Over time, that inefficiency can affect your overall metabolic function, and because testosterone production depends on healthy cellular and metabolic processes, this may indirectly influence hormone balance

Eur J Biochem 267:49044911 Krahenbuhl S, Krahenbuhl-Glauser S, Stucki J, Gehr P, Reichen J (1992) Stereological and functional analysis of liver mitochondria from rats with secondary biliary cirrhosis: impaired mitochondrial metabolism and increased mitochondrial content per hepatocyte