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It is caused because ROS has unpaired electrons, providing a higher chemical reactivity, and making it act as a potentially toxic molecule to induce an amount of degenerative disease by damaging the biomolecules [20]

10.1038/nchembio.2239 34 DolmaS.LessnickS

This is why some practitioners prefer it not just for multi-dose use but specifically because it's designed to remain chemically stable in a vial over an extended period