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The relative contribution of each system is different depending on the cell type, as discussed in the following section

53 When two mitochondria get closer, Mfn1 or Mfn2 interact between the outer membranes of the two mitochondria

In this setting, CYP2A6 metabolism and conversion of nicotine to its metabolites is unlikely and consequently high metabolite concentrations, typically reported in humans, were not observed