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Since its inception in the early 1940s, Waddingtons concept of epigenetics took on additional meanings until encompassing the current notion of stochastic or environment-induced modifications of histone proteins or DNA without changes in the DNA sequence itself that alter the accessibility of genes to transcription factors [9]

doi: 10.3389/fendo.2018.00476 102 ZhouX.ZhangY.WuX.WanD.YinY

What is their signicance as signals in the absence of ROS-driven changes in redox state

Identifying these phenotypes enables patient stratification and supports the development of targeted therapeutic strategies aligned with precision-medicine principles