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A.MarsM.EstebanM.

(2009) A functional analysis of the CREB signaling pathway using HaloCHIP-chip and high throughput reporter assays

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Hence, functional vitamin B12 is required to raise levels of S-Adenosylmethionine (SAM), but SAM in turn is required for activation of the B6-dependent enzyme CBS, which is involved in converting homocysteine to cystathionine