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The number of replicates performed is detailed in each figure legend, where applicable

The compounds direct activity at GHS-R1a receptors expressed on cardiomyocytes produces a transient inotropic effect an increase in the force of cardiac contraction within 15 minutes of administration

On the other hand, protective effects of Mn were observed in studies evaluating endothelial cells exposed to conditions associated with diabetes [120, 121], a metabolic disorder characterized by endothelial dysfunction resulting from inflammation, oxidative stress, and advanced glycation end-products (AGEs) [122]