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Chen and Gallie 2008)

Authors showed that elevated temperature (39-40C) restricts SARS-CoV-2 infection and replication independently of interferon-mediated antiviral defenses

52 NoelG.DoucetM.NataroJ

Mitochondrial dysfunction serves as both a cause and a consequence of chronic neuroinflammatory diseases

At lower concentrations, GSDMD-NT forms non-lytic pores, which are more conducive to the release of pro-inflammatory cytokines rather than to cell death, compared to higher concentrations [183]