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Trimethylamine-N-Oxide promotes Age-related vascular oxidative stress and endothelial dysfunction in mice and healthy humans

[DOI] [PubMed] [Google Scholar] 281.Langendonk JG, Balwani M, Anderson KE, Bonkovsky HL, Anstey AV, Bissell DM, Bloomer J, Edwards C, Neumann NJ, Parker C, Phillips JD, Lim HW, Hamzavi I, Deybach JC, Kauppinen R, Rhodes LE, Frank J, Murphy GM, Karstens FPJ, Sijbrands EJG, de Rooij FWM, Lebwohl M, Naik H, Goding CR, Wilson JHP, Desnick RJ

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Table 2 summaries the microbial metabolites of EC that have demonstrated anti-inflammatory effects, along with their precursors, experimental models, and underlying mechanisms

Structural alerts and in silico de-risking activities Structure-activity relationships are one of the fundamentals of pharmacology and over the course of 5 decades, the work of several visionary toxicologists translated this to genotoxicity and then to applications in sensitization/toxicity