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Formation and Mechanism Long-term UV exposure triggers melanin production to prevent sun damage Oxidative stress due to heat damages skin cells Appearance Face, hands, arms, neck, and feet Distinguishing Features Uneven tanning of the body (Appears only on the exposed areas Freckles or sun spots Often appears with aging Uneven Skin Tone In uneven skin tone, there are no defined dark spots, but general skin dullness or patchy pigmentation

H.Gomez-SierraT.Martinez-KlimovaE.Pedraza-ChaverriJ

Each round of model optimisation was guided by cross-correlation between the map and the model

Overall, high concentrations of reactive species produced by immune response, oxidative metabolism, and other environmental factors create a complex landscape of oxidative stress that the parasite has to deal with to maintain redox homeostasis for its survival in diverse hosts

Rosenberg M, Curhan GC, Forman JP