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Furthermore, the downregulation of FA metabolism-related genes in postmenopausal women leads to excessive lipid deposition in skeletal muscle, adipose tissue, and bone marrow, which in turn impairs FAO

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On average, volunteers in the retatrutide clinical trial who received the study drug rather than a placebo lost an average of 70.3 pounds over about a year-and-a-half, with more than 45% of participants losing more than 30% of their body weight