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Some high-burden malignancies, such as colorectal (CRC), head and neck (HNC), lung (lung cancer), prostate (prostate cancer), and esophageal (gastric cancer) cancers, have shown mixed or positive prognostic implications for TAMs, rather than only negative ones (7)

5-HTP can also increase levels of melatonin, dopamine, and norepinephrine (28) (29) , compounds involved in mood and sleep regulation and whose mechanistic pathways may also be stimulated (2)