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MAM formation, interactions between voltage-dependent anion-selective channel 1 (VDAC1) and inositol 1,4,5-triphosphate receptor type 1 (IP3R1), pancreatic -cell apoptosis and proliferation were detected using transmission electron microscopy (TEM), proximity ligation assay (PLA), terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay, immunofluorescence staining, and Western blotting

The raw reads were trimmed and aligned to the reference Mus musculus genome by the HISAT2 software

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Because these systemic immune responses are hallmarks of chronic inflammation in immune-mediated inflammatory diseases, these findings suggest therapeutic benefits beyond the skin