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Abbreviations AB: Antibiotic ABs: Antibiotics AECOPD: Acute exacerbation of chronic obstructive pulmonary disease CAP: Community acquired pneumonia CI: Confidence interval COPD: Chronic obstructive pulmonary disease CRP: C-reactive protein ED: Emergency department GRADE: Grading of Recommendations Assessment, Development, and Evaluation ICU: Intensive care unit LOS: Length of stay LRTI: Lower respiratory tract infection MD: Mean difference MDRO: Multidrug-resistant organism OR: Odds ratio PCR: Polymerase chain reaction PCT: Procalcitonin RCT: Randomized controlled trial RCTs: Randomized controlled trials ROB: Risk of bias SD: Standard deviation SE: Standard error SOC: Standard of care SOFA: Sequential organ failure assessment or Sepsis-related organ failure assessment UTI: Urinary tract infection VAP: Ventilator-associated pneumonia References de Kraker MEA, Stewardson AJ, Harbarth S

However, despite mucosal GSH depletion, there was no evidence of mucosal injury as revealed by the lack of histologic changes of samples from DEM-treated rats

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