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Glutamine, a conditionally essential amino acid, serves as a metabolic substrate for enterocytes, and reduces bacterial translocation and production of pro-inflammatory cytokines.11 Meanwhile, taurine has the role of maintaining the membrane potential and the intracellular pH, as well as modulating apoptosis (Fig

The vulnerability of this system to free radicals demand for advanced strategies to combat them

in Table 2), and pharmacological, behavioral, and peripheral interventions that also affect the brain such as neurotransmitter modulators (e.g., duloxetine, bupropion), peripheral nerve stimulation (transcutaneous electrical nerve stimulation, scrambler therapy, vagus nerve stimulation), meditation, exercise, and cognitive behavioral therapy or combination therapies to amplify an interventions effect on the brain (e.g., tDCS during exercise, duloxetine plus exercise)

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