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[,] Heavy metals play a crucial role in inducing oxidative stress that is caused by an imbalance between the production and elimination of ROS

However, the guidelines do not recommend antiviral therapy for HBeAg-positive chronic HBV infection (immune-tolerant, IT) patients

Another critical area is the search for biomarkers and surrogate endpoints related to the MGBA

doi: 10.1016/j.jep.2009.03.038

Through a comprehensive review of current literature, we aim to offer an updated view of advances in understanding this enigmatic disease, as well as new therapeutic perspectives emerging from this knowledge