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Antibiotic potentiation in multidrug-resistant Gram-negative pathogenic bacteria by a synthetic Peptidomimetic

Tracy Rabin Associate Professor Yale School of Medicine Rondi Kauffmann Associate Professor of Surgery, Vanderbilt University Medical Center Margaret Akey Medical Student University of California San Francisco School of Medicine James Hudspeth Clinical Associate Professor, Medicine, General Internal Medicine, Boston University Chobanian and Avedisian School of Medicine Michelle Arteaga Global Engagement Programs Manager, Stanford University School of Medicine Moderator: Barbara Kamholz Rationale: Elderly Populations in Low and Middle Income Countries (LMIC) are increasing at rates 2-3 times faster than in High Income Countries (HICs)

GHRP-2 has a half-life of roughly 1560 minutes - too short for once-daily dosing to maintain GH pulsatility

Peptide reconstitution is the process of adding bacteriostatic water or another approved diluent to a peptide vial before use

References PubMed Prolonged stimulation of GH and IGF-1 secretion by CJC-1295 in healthy adults PubMed Once-daily CJC-1295 normalizes growth in GHRH knockout mouse PubMed Ipamorelin, the first selective growth hormone secretagogue PMC Beyond the androgen receptor: GH secretagogues in body composition management PubMed Pharmacokinetic-pharmacodynamic modeling of ipamorelin in human volunteers PubMed Ipamorelin GH pulse kinetics and timing studies CDC Vaccine administration: subcutaneous route (angle/site