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Benefits have been observed in a wide range of dosages

Mitochondrial dysfunction prevents repolarization of inflammatory macrophages

Patients who developed fibrosis (n=434

As expected, endo-IWR1, a specific inhibitor of canonical Wnt/-catenin signaling by increasing degradation of -catenin 25,26 , substantially reduced the expression of -catenin in a dose-dependent manner (Supplementary Figure 4a)