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Additionally, proteolysis targeting chimeras (PROTACs) offer a novel approach to modulate ferroptosis: PROTACs targeting ACSL4 or Nrf2 have been developed to either induce ferroptosis (in renal cell carcinoma) or enhance antioxidant defense (in CKD), respectively, with improved specificity compared to small-molecule inhibitors

The presence of high levels of VEGF-C and tumor lymphangiogenesis is associated with immunosuppression but might also indicate better efficacy for ICB treatment

This system mediates the exchange of extracellular cystine for intracellular glutamate

But they contain other nutrients as well