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And so for detoxification purposes, your body has to keep on producing more and more glutathione all the time

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Notably, a BH 4 deficiency lowers the glutathione (GSH)/glutathione disulfide (GSSG) redox ratio, promotes eNOS S-glutathionylation, and further impairs NO production, thereby contributing to endothelial dysfunction and vascular inflammation with aging [141, 142]

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Levels of urinary polyamines in patients with rheumatoid arthritis